5-MeO-DMT Resources

Here are some resources on 5-MeO-DMT that we've curated. This is an evolving document, and we welcome your suggestions for additions.

Books | Films and Videos | Podcasts | Journalism | Scientific Studies


The Toad and the Jaguar
by Ralph Metzner

An exploration into the history, preparation, and methods of use, for both the natural excretions of the toad as well as synthetic 5-MeO-DMT by one of the pioneers of the field.

Amazon CA
The God Molecule
by Dr. Gerardo Ruben Sandoval

The author, a doctor who has facilitated 5-MeO-DMT for thousands of journeyers, believes that now is the time for 5-MeO-DMT, in this circumstance in human history.

Amazon CA

"It is the only substance I have witnessed capable of showing us who we really are. It removes our ego-made masks and shows us what we are made of…. Light!"

Films and Videos


A documentary about 3 friends taking 5-MeO-DMT, and their reflections on their experiences with the medicine. (73 mins)

Vimeo Prime Video
Hamilton Morris describes the history of 5-MeO-DMT

Hamilton Morris of Hamilton's Pharmacopoeia takes an in-depth look into the history of 5-MeO-DMT. Dense but thorough. (42 mins)

Hamilton's Pharmacopoeia on 5-MeO-DMT

Hamilton Morris travels to meet the toad and the humans that work with the its venom. He explores the history of the first encounter between human and the toad and experiences the god molecule for himself. The documentaries also provide some context on the habitat, milking, and conservation of the toads.

Part 1 Part 2
Pheonix Academic Webinars: Serving 5-MEO
with Trina Nguyen, Dace Mars, and Richard Kay

Three seasoned 5-MEO-DMT facilitators, including our mentor Trina Nugyen, talk about the medicine, their work, and how they began facilitating. (1 hour 59 minutes)

Direct Video Link Pheonix Academy webinars list
Dr. Trina Nguyen, pharmacist and co-founder of Toad School, speaks at Vancouver Psychedelic Society

Trina reminisces on the Shulgins, introduces the only molecule that scores a plus-four on the Shulgin Scale, and describes her processes and the experiences. (51 minutes)



Helena with Mia Cosco
Psychedelic Salons

Helena discusses our process, our backgrounds and their influences on our work, and what we learn and find meaning from our work. (45 minutes)

Microdosing 5-MeO-DMT
Flourish Academy Microdosing 101

Sagan and Helena with host Dana Harvey discuss microdosing 5-MeO-DMT, different routes of administration, creating a safe countainer, and how microdoses of 5-MeO-DMT differ from microdoses of other psychedelics. (1 hour 40 minutes)

Audio Replay Clubhouse App
Journeying Safely with 5-MeO-DMT
One Degree Shifts

Pascal Tremblay of the Kaslo, B.C.-based psychedelic support hub Nectara speaks with Victoria Wueschner, co-founder of F.I.V.E., a 5-MeO-DMT resource centre. Victoria speaks to the ability to get “surgical” with trauma with low- and medium doses and the medicine’s capacity to allow for spiritual exploration on higher doses. (1 hour 9 minutes)

Podcast Homepage Apple Podcasts Google Podcasts Spotify
Steve Rio: Facilitating 5-MeO-DMT Ceremonies, Dying Before Death, and Having A Psychedelic Mindset in the Psychedelic Industry
Modern Psychedelics Podcast

An interview with a local practitioner. (66 mins)

Apple Podcasts Google Podcasts Spotify Podcast Homepage
Dr. Gerardo Sandoval: Exploring the Sacred Power of 5-MeO-DMT and the Psychedelic Toad
Psychedelic Times Podcast

An interview with a long-time practitioner who has worked with thousands of clients. He's a really gentle beautiful soul. (60 mins)

Apple Podcasts Google Podcasts Spotify Podcast Homepage
A Marine, A Monk, and a 5-MeO-DMT Facilitator Walk into a Bar
Entheogenic Evolution Podcast by Martin Ball

“Bernardo” describes his journey from being a marine to a two-decade experience as a monk, and now working as a 5-MeO-DMT facilitator. Martin Ball echos “Bernardo” personal and observed experiences that a human cannot hide on 5-MeO-DMT (1 hour 38 mins)

Apple Podcasts Google Podcasts Spotify Podcast Homepage


5-MeO-DMT: The 20-Minute Psychoactive Toad Experience That’s Transforming Lives
by David E Carpenter at Forbes Magazine


Scientific Studies

A phase 1/2 trial to assess safety and efficacy of a vaporized 5-methoxy-N,N-dimethyltryptamine formulation (GH001) in patients with treatment-resistant depression
by J.T. Reckweg (2023)

Administration of 5-MeO-DMT to a cohort of 16 patients with treatment-resistant depression was well tolerated and provided potent and ultra-rapid antidepressant effects.

Direct Link
A narrative synthesis of research with 5-MeO-DMT
by A.O. Ermakova (2022)

An overview of research on 5-MeO-DMT covering traditional use, pharmacology, effects and drug interactions.

Direct Link
A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms
by M.V. Uthaug et al. (2019)

See also this article summarizing the findings for a non-scientific audience.

Springer Link Open Access
5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used in a naturalistic group setting is associated with unintended improvements in depression and anxiety
by A.K. Davis et al. (2018)

T&F Online
Intensity of Mystical Experiences Occasioned by 5-MeO-DMT and Comparison With a Prior Psilocybin Study
by J. Barsuglia et al. (2018)

Open Access